Developing Lunar Flashlight and Near-Earth Asteroid Scout Flight Software Concurrently using Open-Source F Prime Flight Software Framework

NASA’s Lunar Flashlight (LF) and Near-Earth Asteroid (NEA) Scout CubeSat missions are planned to launch in 2022. Lunar Flashlight is a low-cost secondary payload concept that will map the lunar South Pole for volatiles and demonstrate several technological firsts, including the first planetary CubeSat mission to use green propulsion, and the first mission to use lasers to look for water ice. NEA Scout is a low-cost concept that will map an asteroid and demonstrate several technological firsts, including being the first CubeSat to reach an asteroid. Flight software for both CubeSat missions is based on the open-source F Prime Flight Software Product Line developed by JPL. F Prime utilizes a reusable component-based architecture with typed ports that can be interconnected to form a topology. Also, F Prime includes a set of auto-coding tools used to generate components and topologies that can be deployed for various mission specific applications. Both CubeSats share a common set of avionics for command and data handling (C&DH), telecom and power. This commonality in hardware is translated to a shared deployment in software enabling concurrent flight software development for both CubeSats. The modularity and reusability in F Prime enable such concurrent flight software development for different applications given a common set of avionics. In particular, F Prime has been used successfully to develop a common software deployment for the Sphinx C&DH platform used on both CubeSats. The common F Prime deployment for Sphinx has also been made open source to provide a starting point for any future F Prime software deployments utilizing the Sphinx platform. This paper provides a comparison between the Lunar Flashlight and NEA Scout Flight Software deployments highlighting the use of a common shared set of F Prime components developed for the Sphinx platform along with general lessons learned for CubeSat flight software development with the F Prime Framework

A Robust Regression-Based Stock Exchange Forecasting and Determination of Correlation between Stock Markets

Knowledge-based decision support systems for financial management are an important part of investment plans. Investors are avoiding investing in traditional investment areas such as banks due to low return on investment. The stock exchange is one of the major areas for investment presently. Various non-linear and complex factors affect the stock exchange. A robust stock exchange forecasting system remains an important need. From this line of research, we evaluate the performance of a regression-based model to check the robustness over large datasets. We also evaluate the effect of top stock exchange markets on each other. We evaluate our proposed model on the top 4 stock exchanges—New York, London, NASDAQ and Karachi stock exchange. We also evaluate our model on the top 3 companies—Apple, Microsoft, and Google. A huge (Big Data) historical data is gathered from Yahoo finance consisting of 20 years. Such huge data creates a Big Data problem. The performance of our system is evaluated on a 1-step, 6-step, and 12-step forecast. The experiments show that the proposed system produces excellent results. The results are presented in terms of Mean Absolute Error (MAE) and Root Mean Square Error (RMSE)

Effect of Different Proportions of Magnesium reinforced Carbon Steel for Excavator Bucket Teeth

Effects of carbon steel with different proportions of magnesium were studied through mechanical properties for escavator bucket teeth applications. In this study, micron-sized magnesium particles were used as reinforcement to fabricate the carbon steel - Mg composites at two casting temperatures (650 and 830 °C) and stirring periods (3 and 6 min). In this regard, escavator bucket teeth are replaced by Magnesium based carbon steel material and it also describes the modeling and analysis of escavator bucket teeth. Tensile strength, bending strength and hardness of Caron steel with magnesium was improved in all proportions when compared to virgin carbon steel and existing chromium steel. These results indicated that, failure can be minimize by improving bucket tooth with fabrication of carbon steel and Magnesium alloy for more efficient digging and ground leveling. The project concludes that, usage of carbon steel-magnesium composites in the place of Excavator teeth; it can achieve reliability with less weight and high strength

High-pressure processing of fish and shellfish products: Safety, quality, and research prospects

Seafood products have been one of the main drivers behind the popularity of high-pressure processing (HPP) in the food industry owing to a high demand for fresh ready-to-eat seafood products and food safety. This review provides an overview of the advanced knowledge available on the use of HPP for production of wholesome and highly nutritive clean label fish and shellfish products. Out of 653 explored items, 65 articles published during 2016-2021 were used. Analysis of the literature showed that most of the earlier work evaluated the HPP effect on physicochemical and sensorial properties, and limited information is available on nutritional aspects. HPP has several applications in the seafood industry. Application of HPP (400-600 MPa) eliminates common seafood pathogens, such as Vibrio and Listeria spp., and slows the growth of spoilage microorganisms. Use of cold water as a pressure medium induces minimal changes in sensory and nutritional properties and helps in the development of clean label seafood products. This technology (200-350 MPa) is also useful to shuck oysters, lobsters, crabs, mussels, clams, and scallops to increase recovery of the edible meat. High-pressure helps to preserve organoleptic and functional properties for an extended time during refrigerated storage. Overall, HPP helps seafood manufacturers to maintain a balance between safety, quality, processing efficiency, and regulatory compliance. Further research is required to understand the mechanisms of pressure-induced modifications and clean label strategies to minimize these modifications

The Prospects of an Active Vaccine Against Asthma Targeting IL-5

Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammation of the lung in allergic mice. More recently, we have demonstrated that eosinophil-mediated skin disease in horses with insect bite hypersensitivity can be strongly reduced by vaccination against IL-5. Here we would like to propose the development of a similar vaccine for the treatment of asthma in humans

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles

Parkinson's disease (PD) is a progressive and currently incurable neurological disorder characterised by the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (a-syn). Oligomeric a-syn is proposed to play a central role in spreading protein aggregation in the brain with associated cellular toxicity contributing to a progressive neurological decline. For this reason, a-syn oligomers have attracted interest as therapeutic targets for neurodegenerative conditions such as PD and other alpha-synucleinopathies. In addition to strategies using small molecules, neutralisation of the toxic oligomers by antibodies represents an attractive and highly specific strategy for reducing disease progression. Emerging active immunisation approaches using vaccines are already being trialled to induce such antibodies. Here we propose a novel vaccine based on the RNA bacteriophage (Qbeta) virus-like particle conjugated with short peptides of human a-syn. High titres of antibodies were successfully and safely generated in wild-type and human a-syn over-expressing (SNCA-OVX) transgenic mice following vaccination. Antibodies from vaccine candidates targeting the C-terminal regions of a-syn were able to recognise Lewy bodies, the hallmark aggregates in human PD brains. Furthermore, antibodies specifically targeted oligomeric and aggregated a-syn as they exhibited 100 times greater affinity for oligomeric species over monomer a-syn proteins in solution. In the SNCA-OVX transgenic mice used, vaccination was, however, unable to confer significant changes to oligomeric a-syn bioburden. Similarly, there was no discernible effect of vaccine treatment on behavioural phenotype as compared to control groups. Thus, antibodies specific for oligomeric a-syn induced by vaccination were unable to treat symptoms of PD in this particular mouse model.</p

Sex differences in procedural and clinical outcomes following rotational atherectomy

Aim: Evaluate sex differences in procedural net adverse clinical events and long‐term outcomes following rotational atherectomy (RA). Methods and Results: From August 2010 to 2016, 765 consecutive patients undergoing RA PCI were followed up for a median of 4.7 years. 285 (37%) of subjects were female. Women were older (mean 76 years vs. 72 years; p &lt; .001) and had more urgent procedures (64.6 vs. 47.3%; p &lt; .001). Females received fewer radial procedures (75.1 vs. 85.1%; p &lt; .001) and less intravascular imaging guidance (16.8 vs. 25.0%; p = .008). After propensity score adjustment, the primary endpoint of net adverse cardiac events (net adverse clinical events: all‐cause death, myocardial infarction, stroke, target vessel revascularization plus any procedural complication) occurred more often in female patients (15.1 vs. 9.0%; adjusted OR 1.81 95% CI 1.04–3.13; p = .037). This was driven by an increased risk of procedural complications rather than procedural major adverse cardiac events (MACE). Specifically, women were more likely to experience coronary dissection (4.6 vs. 1.3%; p = .008), cardiac tamponade (2.1 vs. 0.4%; p = .046) and significant bleeding (BARC ≥2: 5.3 vs. 2.3). Despite this, overall MACE‐free survival was similar between males and females (adjusted HR 1.03; 95% CI 0.80–1.34; p = .81). Procedural complications during RA were associated with almost double the incidence of MACE at long‐term follow‐up (HR 1.92; 95% CI 1.34–2.77; p &lt; .001). Conclusion: Women may be at greater risk of procedural complications following rotational atherectomy. These include periprocedural bleeding episodes and coronary perforation leading to cardiac tamponade. Despite this, the adjusted overall long‐term survival free of major adverse cardiac events was similar between males and females

An Optimisation Model for Designing Social Distancing Enhanced Physical Spaces

YesIn the wake of the COVID-19 pandemic, social distancing has become an essential element of our daily lives. As a result, the development of technological solutions for the design and re-design of physical spaces with the necessary physical distancing measures is an important problem that must be addressed. In this paper, we show how automatic design optimisation can be used to simulate the layout of physical spaces subject to a given social distancing requirement. We use a well known mathematical technique based on the circle packing to address this challenge. Thus, given the dimensions and the necessary constraints on the physical space, we formulate the design as a solution to a constrained nonlinear optimisation problem. We then solve the optimisation problem to arrive at a number of feasible design solutions from which the user can pick the most desirable option. By way of examples, in this paper, we show how the proposed model can be practically applied.University of Bradford’s COVID-19 Response Fund, the Spanish Ministry of Science, Innovation, and Universities (Computer Science National Program) under grant #TIN2017-89275-R of the Agencia Estatal de Investigacion and European Funds (AEI/FEDER, UE

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.

Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice and humans; however, their contribution to recall responses has not been defined. Here, we used two-photon microscopy to visualize BRM cells within the lungs of influenza -virus immune and reinfected mice. Prior to re-exposure, BRM cells were sparsely scattered throughout the tissue, displaying limited motility. Within 24 h of rechallenge, these cells increased their migratory capacity, localized to infected sites, and subsequently differentiated into plasma cells. Alveolar macrophages mediated this process, in part by inducing expression of chemokines CXCL9 and CXCL10 from infiltrating inflammatory cells. This led to the recruitment of chemokine receptor CXCR3-expressing BRM cells to infected regions and increased local antibody concentrations. Our study uncovers spatiotemporal mechanisms that regulate lung BRM cell reactivation and demonstrates their capacity to rapidly deliver antibodies in a highly localized manner to sites of viral replication

One-year outcomes after low-dose intracoronary alteplase during primary percutaneous coronary intervention. The T-TIME randomized trial

No abstract available